Cell Assembly by CMOS/Microfluidic Chip
Kit Parker, Donhee Ham, and R.M. Westervelt
Schematic diagrams illustrating rapid 2D tissue assembly from multiple, salvaged, cell types. A) Cell type A is directed to designated locations on an ECM-micropatterned surface within the microfluidic chamber; B) The homogeneous tissue is complete, with type A cells adhering to, and spreading on, the micropatterned surface. Many cell types will spontaneously form cell-cell junctions when in contact adjacent cells; C) Cell type B is directed into previously designated locations within the tissue completed in B; D) The engineered tissue is completed as these cell type B adheres to the micrppatterned surface, spread, and form cell-cell junctions amongst themselves and with cell type A.