CMOS / Microfluidic Chip for the Manipulation of Biological Systems
Donhee Ham and R.M. Westervelt
By combining the sophistication of CMOS integrated circuits with the biocompatibility of microfluidic systems, powerful new systems can be created to manipulate biological systems. To construct the chip above, a microfluidic system was fabricated at Harvard on top of a custom CMOS integrated circuit made in a foundry. The chip contains a microcoil array with current and control circuits. By energizing microcoils, the chip can trap and move magnetic beads and attached cells through the fluid above, to perform cell sorting or to assemble artificial tissues.